A WORM THAT CARES.

CaRF A Neuronal Transcription Factor that CaREs

In this issue of Neuron, report the discovery of a new transcription factor, CaRF, that contributes to calcium stimulation of the BDNF gene through CaRE1, one of several calcium response elements found in the promoter of the BDNF gene. The CaRF/CaRE1 transcriptional pathway may control the expression of genes critical for activity-dependent, long-term changes in the central nervous system (CNS).

The worm that lived

Organisms age because of the "selection shadow"-the decline of the force of natural selection with age. Seemingly straightforward corollary of this theory is the Medawar-Williams prediction, which maintains that increased extrinsic (non-aging) mortality will result in the evolution of accelerated aging and decreased longevity. Despite its centrality to modern thinking about the ultimate causes ...

Who cares?

User Interfaces; Who Cares?

According to Michael Stonebraker’s experiences, if you select a group of well-known experts in database research and ask them to identify the domains where meeting use+ requirements is of primary importance and at the ‘same time more significant advances are needed and more research should be promoted, user interfaces comes out as number one in the list. This has been the case over the last dec...

Medication adherence: WHO cares?

The treatment of chronic illnesses commonly includes the long-term use of pharmacotherapy. Although these medications are effective in combating disease, their full benefits are often not realized because approximately 50% of patients do not take their medications as prescribed. Factors contributing to poor medication adherence are myriad and include those that are related to patients (eg, subo...